The low representation of African countries in clinical trials is not unusual. Poor visibility of existing sites, limited infrastructure, cultural barriers, misunderstandings of requirements to work in the region, and unpredictable clinical trial regulatory timelines are some of the key issues hindering investments in this area and hence causing a burden to conducting clinical trials within Africa. Carole Wallis and Sofie Vandevyver at Cerba Research offer practical solutions while highlighting the incredible potential of Africa’s advantageous landscape.