With an ever-increasing amount of clinical trials reporting significant benefits in long-term overall survival of patients with specific cancers following mono-immunotherapy, the goal has shifted to attaining higher response rates in broader patient populations by employing immuno-oncology (IO) combination approaches. Oana Draghiciu et al. of SMS-oncology present research aimed to shed light on the discovery of effective IO combinations and specific tumour indications in which they can attain durable and long-lasting anti-tumour immune responses, by anticipating new developments in the IO field and identifying trends.