Current Edition

Clinical Research in Rare Diseases: Adult Onset Still’s Disease

Adult onset Still’s disease (AOSD) is a rare inflammatory joint disease of unknown aetiology, characterised by arthritis, fevers spiking once or twice a day, salmon-coloured maculopapular rash and inflammatory involvement of extraarticular organs like serous membranes, the liver and the spleen. Zoltán Vincze et al of Europital examine the clinical presentation and types of AOSD, pathogenesis and diagnostics, baseline therapies, biologicals in the management of AOSD, and conclusions and shortcomings of clinical research in AOSD.