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How Changes in Practice are Changing Bleeding End Points in Coronary Interventional Trials

Cardiac catheterisation and coronary intervention both require catheters to be placed into arteries – engendering risk. In their paper, L. Allen Kindman, Joshua Betcher and Philip Galtry of Quintiles illustrate how the bleeding risk during cardiac catheterisation and percutaneous coronary intervention (particularly for acute myocardial infarction) has been largely mitigated since the original TIMI Group studies (Thrombolysis In acute Myocardial Infarction) were performed in the 1980s.