There has been a difficulty with patient recruitment if patients are homebound or reluctant to go to clinics, or if clinics allow only essential or critical visits or refuse to take part in trials. Obtaining informed consent for trial participation has typically taken place face to face, but with this not being possible due to COVID restrictions, the industry should attempt to move to electronic consent methods. James Klingelhoefer and Ben Singleton at Peli BioThermal demonstrate some of the challenges to clinical trials during a pandemic.