Challenges in Conducting Tuberculosis Clinical Trials in Developing Countries: Lessons Learned
Tuberculosis is a global epidemic of considerable proportions. It is also closely entwined with the human immunodeficiency virus/ acquired immunodeficiency syndrome (HIV/AIDS). There is a great need for new drugs, vaccines, and diagnostics in this therapeutic area, but there are many challenges in the successful operational execution of the requisite clinical trials in developing countries. Rick Turner, Kristin Croucher and Fiona Kershaw at Quintiles review these challenges and offer some ‘lessons learned’ in the execution of clinical trials for TB vaccines, treatment, and diagnostics across Africa, Asia-Pacific, Latin America, and Eastern Europe over the past 10 years.