The clinical monitoring cost is one of the major costs and accounts for one-third of the overall cost of clinical trial management. As the complexities in clinical trials have increased significantly in the last few years, the clinical monitoring cost, and in turn the trial management cost, has increased immensely in order to achieve higher data quality and better monitoring of patient safety. Within the following editorial, Ashok Ghone, PhD, Vice-President, Global Services at Makro Care USA, talks about centralised monitoring.