Emphasis in acute pain studies has shifted to outcomes that go beyond “good pain relief” to reductions in the risk of developing chronic pain, acute medical conditions, and the development of psychological disturbances due to pain. However, there is relatively little direction on the appropriate design and conduct of pain experienced in burn patients. In this review, Jayne Abraham, Director of Medical and Scientific Affairs for Neuroscience at Worldwide Clinical Trials, summarises design-important issues in burn pain management studies with an emphasis on the challenges in burn pain clinical trials
https://www.jforcs.com/7/wp-content/uploads/2016/01/Burn-trauma….pdf