Christene Leiper of Onorach examines clinical trials in Latvia and Lithuania, which have been conducted since the early 1990s. The number of studies has increased every year, reaching a peak in 2008 when 105 new clinical trials authorisations were issued in Lithuania, and 88 in Latvia. Despite a decline in the authorisation of new clinical trials due to the global economic crisis, the new clinical trial application dynamics can now be considered as stable, with 244 ongoing studies in Lithuania and 196 in Latvia.