It is well-established that patients with chronic kidney disease (CKD) have a significantly higher cardiovascular risk than those with normal renal function. In fact, the majority of patients with stages 3 to 4 CKD are more likely to die of CV causes than they are to progress to renal failure. Bobby Stutz and Dr Winter of Atcor Medical, Inc. address the fact that an increased prevalence of major CV risk factors in this population (including hypertension, diabetes, and dislipidemia) does not explain the discrepancy.
http://jforcs.com/jcs/wp-content/uploads/2014/04/The-Role-of-the-Artery-in-Chronic-Kidney-Disease.pdf