One need not conduct a literature review to readily identify treatments in popular culture that have had a tremendous impact on societal health: for example, penicillin and the polio vaccine come immediately to mind. Indeed, the evolution of clinical research from its early beginnings to the sophisticated machine we see today has been extraordinary, generating vast amounts of data, conclusions, and even more research questions. David Cameron, at Quintiles, shares his case studies and recommendations on patient perspective and clinical research study designs.
https://www.jforcs.com/7/wp-content/uploads/2016/07/Integrating-the-Patient.pdf