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Evolving Methodologies in Cardiac Safety: Introduction to a Mini-Seriess
Editorial Archive

Evolving Methodologies in Cardiac Safety: Introduction to a Mini-Seriess

Rick Turner, PhD, Senior Director of Quintiles Cardiac Safety Center of Excellence, submits the first instalment of a miniseries on cardiac safety. The ICH E14 and IC...
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T-peak to T-end: Additional Potential Biomarkers of Interest in the Field of Cardiac Safety
Editorial Archive

T-peak to T-end: Additional Potential Biomarkers of Interest in the Field of Cardiac Safety

Timothy Callahan, PhD, Chief Scientific Officer at Biomedical Systems, writes a paper on how regulatory interest and then, by necessity, drug development and scientif...
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Use of Concentration-effect Modelling for Cardiac Safety ECG Assessments
Editorial Archive

Use of Concentration-effect Modelling for Cardiac Safety ECG Assessments

Robert B. Kleiman, MD, Chief Medical Officer at ERT, shares his knowledge of concentration-effect modelling (CEM), a method of data evaluation which is also commonly ...
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Off-target Blood Pressure Effects in Biopharmaceutical Therapeutic Treatment Development: Points to Consider
Editorial Archive

Off-target Blood Pressure Effects in Biopharmaceutical Therapeutic Treatment Development: Points to Consider

In this Special Feature column, Jeff Heilbraun, MS, Senior Director of Strategic Development at Bioclinica Cardiac Safety observes that, over the past five years, the...
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