Today, a range of Bayesian methods or techniques are being used to drive some of the most important scientific advancements of our age, from novel oncology drugs and pandemic vaccines to medical device innovation. Bayesian methods offer powerful predictive capabilities and evidence-based hypothesis adjustment, leading to de-risked and expedited clinical trials. Ofir Harari, Pantelis Vlachos and Yannis Jemiai at Cytel analyse how Bayesian methods are transforming the future of clinical research.