2018 and beyond seems to be the era of predictive analytics, and data is leading the way. Is the fourth age a systems revolution rather than a product revolution? This is truly disruptive technology which could change the way we manage clinical trials and medicine in the future. Christene Leiper of Onorach explores how technologies are fusing the digital and biological worlds, and that doctors will have to prepare themselves for an AI-led health system, bringing humanity to the machine-led interface.